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Measurement Webinar - "Data Linkage" featuring Kimberlyn McGrail, PhD (Scientific Director, Population Data BC) and Anne Gadermann, PhD (Assistant Professor, Human Early Learning Partnership, School of Population and Public Health). August 1, 2019, 11am-noon PT. REGISTER HERE.

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LCRN is actively seeking additional funding to develop new and innovative transdisciplinary research and activities.

The Development of Self-Regulation: Foundational Skills for Children’s Health and Well-Being

By Megan McClelland

This webinar, part of the LCRN’s series based on the Handbook of Life Course Health Development, features Megan McClelland, PhD.   Dr. McClelland will discuss the importance of self-regulation for health, educational success, and well-being over time and across contexts. She will examine the pathways of self-regulatory development (including individual, contextual and sociocultural factors that influence the development of these skills over time), the methods for studying self-regulation, and translational issues such as intervention efforts to improve these skills in children.   Dr. McClelland is the Katherine E. Smith Professor of Healthy Children and Families in Human Development and Family Sciences at Oregon State University (OSU), where she serves as Director …

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Fetal programming of Parkinson’s and Alzheimer’s diseases: the role of epigenetic factors

By Monica Piras, Vassilios Fanos, Alberto Ravarino, Maria Antonietta Marcialis, Laura Vinci, Maria Cristina Pintus and Gavino Faa

In this paper, the main epigenetic factors involved in shaping the brain’s physical structure during development will be reviewed, with special emphasis on those related to Parkinson’s disease and Alzheimer’s disease in adulthood. These factors are: preterm delivery, maternal diet, trace metals, intrauterine infection, maternal stress, drugs, alcohol. Epigenetics may allow a novel therapeutic and preventive approach for neurodegeneration.   Read full article  

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Adult mental health disorders and their age at onset

By PB Jones

The study of age at onset of mental health disorders is technically and conceptually difficult. It is important to consider these age distributions in order to understand causes and mechanisms of illness and to intervene at an appropriate juncture for primary and secondary prevention. This article reviews some of the approaches to studying age at onset, sets out the evidence to support the assertion that adult mental disorders begin in adolescence, and finds that perhaps half of all adult mental health disorders have begun by the teenage years. The paper then discusses whether this fits what is known about the developmental neurobiology of the brain and introduces the implications for …

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Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study

By I Shalev, TE Moffitt, K Sugden, B Williams, RM Houts, A Danese, J Mill, L Arseneault and A Caspi

There is increasing interest in discovering mechanisms that mediate the effects of childhood stress on late-life disease morbidity and mortality. Previous studies have suggested one potential mechanism linking stress to cellular aging, disease and mortality in humans: telomere erosion. We examined telomere erosion in relation to children’s exposure to violence, a salient early-life stressor, which has known long-term consequences for well-being and is a major public-health and social-welfare problem. Compared with their counterparts, the children who experienced two or more kinds of violence exposure showed significantly more telomere erosion between age-5 baseline and age-10 follow-up measurements, even after adjusting for sex, socioeconomic status and body mass index. This finding provides …

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Childhood cumulative risk and obesity: the mediating role of self-regulatory ability

By GW Evans, TE Fuller-Rowell and SN Doan

We tested whether early childhood risk exposures are related to weight gain in adolescence and evaluate an underlying mechanism, self-regulatory behavior, for the risk-obesity link. Nine-year-old children exposed to a greater accumulation of multiple risk factors show larger gains in adiposity over the next four year period, net of their initial BMI. These gains in BMI during early adolescence are largely accounted for by deteriorated self-regulatory abilities among children facing more cumulative risks. Early childhood risk exposure leads to larger gains in BMI in adolescence. Given the importance of childhood adiposity to the development of obesity later in life, understanding the underlying mechanisms that link early experience to weight gain …

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Self-regulation: the integration of cognition and emotion

By MM McClelland, C Cameron Ponitz, E Messersmith and S Tominey

This chapter examines self-regulation across the life span with a focus on integrating cognition and emotion. First, we situate self-regulation in a theoretical context and describe the conceptual foundations that have informed its study across multiple sources of influence, settings, and over time. We then discuss how self-regulation has been defined and operationalized in diverse fields over the life span including developmental, personality, cognitive and educational perspectives. Next, we review measurement issues including the what, where and how to assessing self-regulation from a multidimentional perspective. Finally, we discuss the development of self-regulation over the life span and conclude the chapter with common themes, implications and future directions for research and …

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