Upcoming Webinars


Click here to view recordings of previous webinars

Measurement Webinar - "EDI in US Cities" featuring Neal Halfon, MD, MPH and Lisa Stanley, DrPH. February 12, 2019, 1-2:30PM PST. REGISTER HERE.

Measurement Webinar - "EDI in Australia" featuring Sharon Goldfeld, FRACP, FAFPHM, PhD. March 5, 2019, 1-2:30 PM PST. REGISTER HERE.

Support Us

LCRN is actively seeking additional funding to develop new and innovative transdisciplinary research and activities. If you would like to contribute, please contact Ericka Tullis, Project Manager, at ETullis@mednet.ucla.edu.

Prenatal, perinatal, early life, and sociodemographic factors underlying racial differences in the likelihood of high body mass index in early childhood

By MM Weden MM, P Brownell P and MS Rendall

OBJECTIVES: We investigated early childhood disparities in high body mass index (BMI) between Black and White US children. METHODS: We compared differences in Black and White children’s prevalence of sociodemographic, prenatal, perinatal, and early life risk and protective factors; fit logistic regression models predicting high BMI (≥ 95th percentile) at age 4 to 5 years to 2 nationally representative samples followed from birth; and performed separate and pooled-survey estimations of these models. RESULTS: After adjustment for sample design-related variables, models predicting high BMI in the 2 samples were statistically indistinguishable. In the pooled-survey models, Black children’s odds of high BMI were 59% higher than White children’s (odds ratio [OR] = …

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Stress and the brain: how experiences and exposures across the life span shape health, development, and learning in adolescence

By Sara B. Johnson and Robert W. Blum

Recognizing the utility of a life course perspective, this special issue of the Journal of Adolescent Health examines the impact of experience in shaping brain and behavior from the prenatal period through adolescence. This issue is based on a conference, “Stress and the Brain: Implications for Health, Development and Learning,” held at the Johns Hopkins Bloomberg School of Public Health in April 2011. It was a collaboration of the Schools of Education and Public Health and was sponsored by the Carol and Eugene Ludwig Fund. The conference brought together a multidisciplinary group of experts to consider the role of stress, adversity, and experience broadly defined, during the prenatal, childhood, and …

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Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study

By I Shalev, TE Moffitt, K Sugden, B Williams, RM Houts, A Danese, J Mill, L Arseneault and A Caspi

There is increasing interest in discovering mechanisms that mediate the effects of childhood stress on late-life disease morbidity and mortality. Previous studies have suggested one potential mechanism linking stress to cellular aging, disease and mortality in humans: telomere erosion. We examined telomere erosion in relation to children’s exposure to violence, a salient early-life stressor, which has known long-term consequences for well-being and is a major public-health and social-welfare problem. Compared with their counterparts, the children who experienced two or more kinds of violence exposure showed significantly more telomere erosion between age-5 baseline and age-10 follow-up measurements, even after adjusting for sex, socioeconomic status and body mass index. This finding provides …

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Building a new biodevelopmental framework to guide the future of early childhood policy

By Jack P. Shonkoff

Four decades of early childhood policy and program development indicate that evidence-based interventions can improve life outcomes, and dramatic advances in the biological and behavioral sciences now provide an opportunity to augment those impacts. The challenge of reducing the gap between what we know and what we do to promote the healthy development of young children is to view current best practices as a starting point and to leverage scientific concepts to inspire fresh thinking. This article offers an integrated, biodevelopmental framework to promote greater understanding of the antecedents and causal pathways that lead to disparities in health, learning and behavior in order to inform the development of enhanced theories …

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How experience gets under the skin to create gradients in developmental health

By Clyde Hertzman and W. Thomas Boyce

Social environments and experiences get under the skin early in life in ways that affect the course of human development. Because most factors associated with early child development are a function of socio-economic status, differences in early child development form a socio-economic gradient. We are now learning how, when and by what means early experiences influence key biological systems over the long term to produce gradients: a process known as biological embedding. Opportunities for biological embedding are tethered closely to sensitive periods in the development of neural circuitry. Epigenetic regulation is the best example of operating principles relevant to biological embedding. We are now in a position to ask how …

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Early childhood health promotion and its life course health consequences

By Bernard Guyer, Sai Ma, Holly Grason, Kevin D. Frick, Deborah F. Perry, Alyssa Sharkey and Jennifer McIntosh

To explore whether health promotion efforts targeted at preschool-age children can improve health across the life span and improve future economic returns to society, we selected 4 health topics to review—tobacco exposure, unintentional injury, obesity, and mental health—that are clinically and epidemiologically significant, and represent the complex nature of health problems in this early period of life. The peer-reviewed literature was searched to assess the level of evidence for short and long-term health impacts of health promotion and disease prevention interventions for children from before birth to age 5. This review sought to document the monetary burden of poor child health, the cost implications of preventing and treating child health …

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The fetal and infant origins of adult disease

By DJ Barker

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